Pseudocontinuous Arterial Spin Labeling Reveals Dissociable Effects of Morphine and Alcohol on Regional Cerebral Blood Flow
نویسندگان
چکیده
منابع مشابه
Pseudocontinuous arterial spin labeling reveals dissociable effects of morphine and alcohol on regional cerebral blood flow
We have examined sensitivity and specificity of pseudocontinuous arterial spin labeling (PCASL) to detect global and regional changes in cerebral blood flow (CBF) in response to two different psychoactive drugs. We tested alcohol and morphine in a placebo-controlled, double-blind randomized study in 12 healthy young men. Drugs were administered intravenously. Validated pharmacokinetic protocols...
متن کاملAccuracy of Parenchymal Cerebral Blood Flow Measurements Using Pseudocontinuous Arterial Spin-Labeling in Healthy Volunteers.
BACKGROUND AND PURPOSE The arterial spin-labeling method for CBF assessment is widely available, but its accuracy is not fully established. We investigated the accuracy of a whole-brain arterial spin-labeling technique for assessing the mean parenchymal CBF and the effect of aging in healthy volunteers. Phase-contrast MR imaging was used as the reference method. MATERIALS AND METHODS Ninety-t...
متن کاملPseudocontinuous arterial spin labeling quantifies relative cerebral blood flow in acute stroke.
BACKGROUND AND PURPOSE The aim of this study was to test whether arterial spin labeling (ASL) can detect significant differences in relative cerebral blood flow (rCBF) in the core, mismatch, and reverse-mismatch regions, and whether rCBF values measured by ASL in those areas differ from values obtained using dynamic susceptibility contrast (DSC) MRI. METHODS Acute stroke patients were imaged ...
متن کاملSuperselective pseudocontinuous arterial spin labeling.
A new technique for the imaging of flow territories of individual extra- and intracranial arteries is presented. The method is based on balanced pseudocontinuous arterial spin labeling but employs additional time-varying gradients in between the radiofrequency pulses of the long labeling train. The direction of the additional gradient vector is perpendicular to the selected artery and its azimu...
متن کاملRobust Cerebral Blood Flow Map Estimation in Arterial Spin Labeling
Non-invasive measurement of Cerebral Blood Flow (CBF) is now feasible thanks to the introduction of Arterial Spin Labeling (ASL) Magnetic Resonance Imaging (MRI) techniques. To date, the low signalto-noise ratio of ASL gives us no option but to repeat the acquisition in order to accumulate enough data to get a reliable signal. Perfusion signal is usually extracted by averaging across the repeti...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Cerebral Blood Flow & Metabolism
سال: 2011
ISSN: 0271-678X,1559-7016
DOI: 10.1038/jcbfm.2010.234